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6-K
OBSEVA SA filed this Form 6-K on 03/30/2018
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Blocking PGF2α receptor has potential to treat PTL with improved safety over NSAIDs Phospholipids ArachidonicAcid Indomethacin PGHS-1/2 = COX1/2 PGH2 PGE2 PGF2α EP1 EP2    FP EP3 EP4 UTERUS:    CONTRACT RELAX CONTRACT ‘Inflammation’    Prostaglandins    Cytokines Chemokines Phospholipids ArachidonicAcid PGHS-1/2 = COX1/2 PGH2 OBE022 PGE2 PGF2α EP1 EP2    FP EP3 EP4 UTERUS: CONTRACT RELAX CONTRACT kidney, brain, vascular smooth muscle Vasoconstriction of ductus arteriosus, renal and mesenteric arteries Platelet aggregation inhibition RUPTURE CONTRACT DILATE PGF2α contracts the myometrium and PGF2α metabolites rise in amniotic fluid before and during labor PGF2α upregulates enzymes causing cervix dilatation and membrane rupture